Results 41 to 50 of about 8,343,043 (294)

Elite and Everyday Social Contracts in Bosnia and Herzegovina: Pathways to Forging a National Social Contract?

Journal of Intervention and Statebuilding, 2020
The Dayton Peace Agreement ended the violence in Bosnia–Herzegovina, however, it also solidified antagonistic political identities leading to the creation of two social contracts: an ‘elite social contract’ involving primarily political elites of the ...
R. Belloni, Jasmin Ramović
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Benefits of home-based foot neuromuscular electrical stimulation on self-reported function, leg pain and other leg symptoms among community-dwelling older adults: a sham-controlled randomised clinical trial

BMC Geriatrics
Introduction Lower leg pain and symptoms, and poor leg circulation are common in older adults. These can significantly affect their function and quality of life.
Binoy Kumaran, Darren Targett, Tim Watson   +2 more
doaj   +1 more source

Building Walls, Social Groups and Empires: A Study of Political Power and Compliance in the Neo-Assyrian Period

Asia Anteriore Antica, 2023
This contribution aims to use social history and social theory to investigate political power and compliance with authority in ancient Western Asia, through the case study of Neo-Assyrian imperial building projects.
Marta Lorenzon, Caroline Wallis
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Open Science and Its Enemies: Challenges for a Sustainable Science–Society Social Contract

, 2020
Science as a social institution has evolved as the most powerful, highly influential, and sought out institution after the conflicts between science and religion following Galileo.
V. Krishna
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Deontic logic and adaptive algorithms: The relevance of explicit benefit in versions of the selection task

Filosofia Unisinos, 2013
Social contract theory argues that to properly execute thematic versions of the selection task one has to specify, in the rules of such versions, an explicit benefit that can only be achieved in exchange for meeting a requirement.
Miguel López Astorga
doaj   +1 more source

The 1991 Constituent Process of as an Example of Deliberative Democracy

Jurídicas, 2023
The 1991 c o n s t i t u e n t process incorporates various elements from the social context of the time, both institutional and non-institutional. These include the “Séptima papeleta” movement, which played a decisive role when the Supreme Court of ...
Eric Leiva Ramírez
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source