Results 91 to 100 of about 475,496 (302)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Global Qualitative Nursing Research, 2017 In this study, researchers compare and contrast issues regarding diabetes self-management between persons in good versus poor glycemic control. The sample comprises low-income racially diverse adults with diabetes from four mid-western community health ...
Jimmy Reyes +4 more
doaj +1 more source
Economia criminale, riappropriazione delle terre e ‘altreconomia’ nel Mezzogiorno
Scienze del Territorio, 2018 As well as representing a presidium of legality and contributing to re-inject in formal economy a huge mass of resources retrieved from shadow economy, the management for social purposes of properties confiscated to the mafia (a growing phenomenon in ...
Tonino Perna
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
To control or not control: A coordination perspective to scaling [PDF]
Over the past few years, the question of how social enterprises can effectively scale their impact to reach people and communities has received increasing attention from various parties such as policy makers, governments, various organizational leaders ...
Mair, Johanna, Sezgi, Funda
core
SystemsCorporate governance is a complex, adaptive open system; yet it is usually modeled, in the classical agency tradition, as a closed matrix of legal and financial contracts. Adopting an open systems perspective, we decode the “social software”—the informal
Vincent O’Connell +1 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
What does the failure to reduce homicides in Venezuela teach?
Revista CIDOB d'Afers Internacionals, 2017 This article addresses the paradox of increased homicides in Venezuela in a period of wealth and redistribution. To do so, theories that explain criminality through poverty and inequality are reviewed and refuted and weighed against theories of ...
Roberto Briceño-León
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Mind the Gap! Social Capital, East and West [PDF]
, 2007 Recent Eurobarometer survey data are used to document and explain the stock of social capital in 28 European countries. Social capital in Central and Eastern Europe ñ measured by civic participation and access to social networks ñ lags behind that in ...
Gërxhani, K. +7 more
core +1 more source