Results 81 to 90 of about 2,768,666 (306)

Contingent Control and Wild Moments: Conducting Psychiatric Evaluations in the Home

open access: yesSocial Inclusion, 2019
When social control and social service workers go into the field, into the “native habitat” of some problem, a variety of tacit structures and controls that mark office work with its standardized documents and formal meetings are weakened or absent ...
Robert M. Emerson, Melvin Pollner
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Simulation and formal verification of industrial systems controllers [PDF]

open access: yes, 2008
Actually, the safety control is one of the most important aspects studied by the international researchers, in the field of design and development of automated production systems due to social (avoid work accidents, ...), economics (machine stop time ...
Campos, J. Creissac   +4 more
core  

Changing the Course of AIDS: Peer Education in South Africa and Its Lessons for the Global Crisis [PDF]

open access: yes, 2009
[Excerpted from the Foreward by Charles Deutsch, Sc.D.] David Dickinson asks the question: How can we inject into the busy, distracted, difficult lives of the least educated and poorest among us the opportunity, and eventually the habit, to think ...
Dickinson, David
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

How Helping Can Reinforce or Attenuate Status Inequalities: The Case of Nonprofit Organizations

open access: yesRSF: The Russell Sage Foundation Journal of the Social Sciences, 2022
This article examines one type of social exchange that signals status: giving and receiving help. I focus on formal helping exchanges between staff and participants in nonprofit organizations.
Lehn M. Benjamin
doaj   +1 more source

Why forums? An empirical analysis into the facilitating factors of carding forums

open access: yes, 2013
Over the last decade, the nature of cybercrime has transformed from naive vandalism to profit-driven, leading to the emergence of a global underground economy. A noticeable trend which has surfaced in this economy is the repeated use of forums to operate
Shadbolt, Nigel   +2 more
core  

Gender and crime: from exclusión to criminalization [PDF]

open access: yes, 2019
La desigualdad de poder entre hombres y mujeres, producto de una socialización dicotómica y jerárquica, que constituye el imaginario de la sociedad patriarcal, trae como consecuencia que la mujer se vea adscrita a unas conductas estereotipadas, de tal ...
Revelles Carrasco, María
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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