Results 51 to 60 of about 1,114,566 (298)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

MOTIVATIONS, IMPORTANCE, CHALLENGES AND PERSPECTIVES OF SOCIAL CONTROL IN HEALTH

Cogitare Enfermagem, 2019
Purpose: To understand the motivations, importance, challenges and perspectives for acting as local health counselors in the Unified Health System.Method: A qualitative and descriptive study of the exploratory type conducted with 15 local health ...
Carlos Junglos, Felipa Rafaela Amadigi, Rosani Ramos Machado, Jacks Sorato   +3 more
doaj   +1 more source

Paying for Crimes and Earning Heaven. Daily Life of Imprisoned Women at “El Buen Pastor” Penitentiary 1890-1929.

Historia y Memoria, 2015
During the period of Colombian conservative hegemony, “El Buen Pastor” prison, in Bogotá, provides an illustration of penitentiary politics, as well as the formal and informal mechanisms of social control at the time, gathered in a single institution. In
July Andrea García Amézquita
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Detecting formal and informal interests in forest governance

MethodsX, 2022
To reveal the interests of actors in forest governance, this paper proposes a power-based interest identification (PII) approach. Based on the assumption of intentional action, the benefits that actors derive from policy impacts are the result of ...
Jiacheng Zhao, Max Krott, Jinlong Liu, Lukas Giessen, Jiayun Dong   +4 more
doaj  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

A justiça de menores portuguesa na viragem do século xxi: uma expressão da cultura do controlo?

e-cadernos ces, 2013
The article relies on the culture of control theoretical assumptions to analyse the impact of neoliberal social policies on Portuguese youth justice. At the turn of the 21st century, Portuguese youth justice was subjected to significant structural and ...
Joana Maduro
doaj   +1 more source

El Control Social, la Familia y las Mujeres

Revista de la Facultad de Derecho, 2014
Aproximación a la noción de control social. Evolución de la concepción del control social. juicio crítico. Un punto de vista clarificador. Grupo social.  Particularidades. Las élites.
Mariana Malet Vázquez
doaj   +2 more sources

Gossip as Social Control: Informal Sanctions on Ethical Violations in Scientific Workplaces

, 2016
Research on misconduct in science has largely focused on egregious violations such as fabrication, falsification, and plagiarism. Recent scholarship, however, calls for greater attention to forms of everyday misconduct and how scientists navigate ethical
B. Vaidyanathan, Simranjit Khalsa, E. Ecklund   +2 more
semanticscholar   +1 more source