Results 51 to 60 of about 434,699 (261)

Master Servant Relationships in the Eastern Cape: the 1820 Settlement

African Studies Quarterly, 2021
This article is about the rebellious behavior of the servant class and the consequent threat it posed to the established social order in the 1820 settlement.
Amina Marzouk Chouchene
doaj  

A justiça de menores portuguesa na viragem do século xxi: uma expressão da cultura do controlo?

e-cadernos ces, 2013
The article relies on the culture of control theoretical assumptions to analyse the impact of neoliberal social policies on Portuguese youth justice. At the turn of the 21st century, Portuguese youth justice was subjected to significant structural and ...
Joana Maduro
doaj   +1 more source

Encounters between security guards and young people: the extent and biases of formal social control

Policing and Society, 2014
There is a distinct lack of knowledge about how the rise of private security relates to young people in adversarial encounters. Prior studies suggest that the policing of young people by police is a common occurrence and social biases exist. However, policing of young people by private security guards has gained much less attention.
Saarikkomäki Elsa, Kivivuori Janne
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

El Control Social, la Familia y las Mujeres

Revista de la Facultad de Derecho, 2014
Aproximación a la noción de control social. Evolución de la concepción del control social. juicio crítico. Un punto de vista clarificador. Grupo social.  Particularidades. Las élites.
Mariana Malet Vázquez
doaj   +2 more sources

Homeless Health Care Simulated Patient Case

MedEdPORTAL, 2007
Introduction In order to appropriately care for a patient who is homeless, physicians must recognize the significance of homelessness to health and respond to the unique challenges that homelessness presents.
Susan Glick, David Buchanan, Louis Rohr, Laura Kehoe   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Contingent Control and Wild Moments: Conducting Psychiatric Evaluations in the Home

Social Inclusion, 2019
When social control and social service workers go into the field, into the “native habitat” of some problem, a variety of tacit structures and controls that mark office work with its standardized documents and formal meetings are weakened or absent ...
Robert M. Emerson, Melvin Pollner
doaj   +1 more source