Results 51 to 60 of about 475,496 (302)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Social Control in Local Communities [PDF]
, 1966 distribution of power. As a matter of fact the author, confronting different views of some distingushed sociologists, points out that in developed industrial societies there is an inclination toward autocratic systems of power and control. However, in
Janez Jerovšek, Jerovšek, Janez
core +1 more source
Historia y Memoria, 2015 During the period of Colombian conservative hegemony, “El Buen Pastor” prison, in Bogotá, provides an illustration of penitentiary politics, as well as the formal and informal mechanisms of social control at the time, gathered in a single institution. In
July Andrea García Amézquita
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Master Servant Relationships in the Eastern Cape: the 1820 Settlement
African Studies Quarterly, 2021 This article is about the rebellious behavior of the servant class and the consequent threat it posed to the established social order in the 1820 settlement.
Amina Marzouk Chouchene
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Trust and Formal Control in interorganizational Relationships [PDF]
There is a tendency to see trust and control by formal agreements as substitutes. According to transaction cost economics trust is unreliable, and some form of control is needed to reduce hazards of opportunism. According to others, high trust allows for
Klein Woolthuis, R., Nooteboom, B.
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Crime control through housing management [PDF]
, 2005 Over the last decade the management of social housing in England and Wales has extended to the formal control of bad behaviour. This thesis charts the political development of this increasingly important function and the legal infrastructure within which
Cobb, Neil Anthony
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