Results 81 to 90 of about 2,729,241 (310)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Responses of Madrasah to Social Change: A Study on Madrasah Aliyah in Bengkulu City

Jurnal Madania, 2020
Madrasah Aliyah is an Islamic educational institution that combines the teaching of religious sciences and general science. Madrasah Aliyah is an agent of change and at the same time Madrasah Aliyah as an object of social change.
Samsudin Samsudin
doaj   +1 more source

Crowding out Informal Care? Evidence from a Social Experiment in Germany [PDF]

This paper evaluates the effects of a professionally assisted consumer-directed program (Personal Budgets) compared to the standard home care programs of the German long-term care insurance.
Arntz, Melanie, Thomsen, Stephan L.
core  

Gender and crime: from exclusión to criminalization [PDF]

, 2019
La desigualdad de poder entre hombres y mujeres, producto de una socialización dicotómica y jerárquica, que constituye el imaginario de la sociedad patriarcal, trae como consecuencia que la mujer se vea adscrita a unas conductas estereotipadas, de tal ...
Revelles Carrasco, María
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Factors Influencing Diabetes Self-Management Among Medically Underserved Patients With Type II Diabetes

Global Qualitative Nursing Research, 2017
In this study, researchers compare and contrast issues regarding diabetes self-management between persons in good versus poor glycemic control. The sample comprises low-income racially diverse adults with diabetes from four mid-western community health ...
Jimmy Reyes, Toni Tripp-Reimer, Edith Parker, Brandi Muller, Helena Laroche   +4 more
doaj   +1 more source

Economia criminale, riappropriazione delle terre e ‘altreconomia’ nel Mezzogiorno

Scienze del Territorio, 2018
As well as representing a presidium of legality and contributing to re-inject in formal economy a huge mass of resources retrieved from shadow economy, the management for social purposes of properties confiscated to the mafia (a growing phenomenon in ...
Tonino Perna
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Pengendalian Sosial Berbasis Modal Sosial Lokal pada Masyarakat di Kalimantan Barat [PDF]

, 2010
This study is about Social Control Based On Social Capital (A Case Study on Dayak-Malay-Madurese at Ketapang Regency, West Kalimantan). The aims of this study are: (1) To know how social interaction exists on multicultural communities at Ketapang Regency;
Asriati, N. (Nuraini), Bahari, Y. (Yohanes)   +1 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source