Results 141 to 150 of about 7,469,552 (341)

Neighborhood Blighted Property Removal and 311 Calls for Non-Emergency Services: A Test of a Marker of Social Control. [PDF]

open access: yesGeogr Anal, 2022
Theall KP   +7 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Visioni dell’educazione: il caso di un penitenziario femminile nell’entroterra paulista

open access: yesDiacronie. Studi di Storia Contemporanea, 2013
The article analyzes the educational process expressed in letters from women inmates and former inmates who participated between 2004 and 2007, of social reintegration program in a women’s prison in Ribeirao Preto, in Sao Paulo state. As the letters were
Wlaumir Donisete de Souza (wlaumir@hotmail.com) si è laureato in Filosofia presso la PUC (Ponteficia Università Cattolica del Rio Grande do Sul) e in Storia presso la Faculdade de História, Direito e Serviço Social dell’Universidade Estadual Paulista Júlio de Mesquita Filho. Si è addottorato in Sociologia presso la Faculdade de Ciências e Letras della stessa università ed è professore nel Centro Universitário Barão de Mauá, a Ribeirão Preto nello Stato di São Paulo.   +1 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The Theory of Social Control and the Social Psychology of Dissatisfaction: Inhibition, regression and isolation in a cultural context

open access: yesGrounded Theory Review: An International Journal, 2011
The Theory of Social Control (TSC) is grounded in satisfaction and happiness research. The study investigated the reasons behind relatively low levels of civil and personal satisfaction, subjective social well-being and experienced happiness in the post ...
Orsolya Selymes, PhD Candidate
doaj  

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