Results 61 to 70 of about 1,415,295 (314)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Social Welfare and Social Control
Japanese Sociological Review, 1994 In the field of welfare and health services for the aged and the disabled, a policy shift from institution-based services to community-based services has gradually introduced in Japan since the early 1980s. At the beginning of the 1980s, this policy shift tended to be seen as an outcome of “disability rights movement” in the 1970s.
openaire +3 more sources
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Utrecht Law Review, 2017 Recent legal scholarship demonstrates increased attention to empirical research in the design and evaluation of law and the policies and practices of legal authorities.
Tom R. Tyler
doaj +1 more source
The Transition to an Objective Standard of Social Control [PDF]
, 1910 L. L. Bernard
openalex +1 more source
Denunciation and Social Control [PDF]
American Sociological Review, 2017 It has long been observed that centralized social control requires some level of cooperation from the populace. Without such assistance, control agents are unable to acquire the local knowledge necessary to locate and prosecute deviants. Yet why citizens cooperate with authorities, especially in the most repressive regimes, remains a puzzle.
openaire +3 more sources
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Introduction: Qualitative Research in Criminology
Forum: Qualitative Social Research, 2002 This paper begins with a brief overview of research traditions that paved the way for qualitative methods in criminological research (labeling approach and critical criminology). In addition, it outlines recent trends in qualitative criminology.
Michael Meuser, Gabi Löschper
doaj