Results 81 to 90 of about 1,518,790 (262)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
1938: a flying man with an S on his breast appears in the sky of an American metropolis, catapulting cartoon mass entertainment into a new dimension. 1986: a spot of blood on a Smiley icon (Moore, 1986) puts an end to the innocence of an entire narrative
Pier Paolo Zampieri
doaj
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Defending Others Online: The Influence of Observing Formal and Informal Social Control on One's Willingness to Defend Cyberhate Victims. [PDF]
Costello M +7 more
europepmc +1 more source
Objective: In this study, we intended to evaluate the impact of Taiwan’s COVID-19 pandemic Level 3 alert on anxiety and mood disorders, focusing on age and gender differences. We hypothesized that individuals aged 43+ years, who experienced the 2003 SARS
Pei-Yi Cheng +3 more
doaj +1 more source
Recent years have witnessed an explosion of interest in predictive policing, with a clear opposition emerging between supporters and critics of its implementation.
Carlo Gatti
doaj
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Disrupted computations of social control in individuals with obsessive-compulsive and misophonia symptoms. [PDF]
Banker SM +6 more
europepmc +1 more source
Recensione / Recension / Book Review [PDF]
Book review of: Bravo F., Criminalità economica e controllo sociale. Impresa etica e responsabilità ex d.lgs.
Vasaturo Giulio
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source

