Results 81 to 90 of about 323,543 (240)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The Need for Responsible Use of AI by Public Administration: Algorithmic Impact Assessments (AIAs) as Instruments for Accountability and Social Control

Abstract AI is increasingly being implemented in the decision-making process of public administration, from the provision of social benefits to public security policies, generating wide impacts on citizen’s fundamental rights. It is expected that governments’ use of AI will increase the efficiency of public management.
openaire   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

FINANCIAL AUDIT AS A PART OF STATE ADMINISTRATION IN UKRAINE: CONDITION AND PUBLIC NEED

Baltic Journal of Economic Studies, 2016
Economic development of countries leads to the need improving the quality of public administration, the results of which provide economic growth, social prosperity and are facilitating to solve global problems that are facing humanity.
Sergey Bardash, Yurii Baraniuk
doaj  

HIV Sero-Prevalence among Tuberculosis Patients in Bangladesh: a nationwide cross-sectional study

Global Biosecurity
Introduction Bangladesh is committed to achieving the SDG target of ending the tuberculosis epidemic and achieving UHC by 2030. To inform policy and program decision-making, this nationwide sero-survey of HIV among tuberculosis patients was conducted ...
Baizid Khoorshid Riaz, Md. Kamrul Amin, Md. Shamiul Islam, ANM Shamsul Islam, Jabin Akhter, Naznin Akter Jahan, Nasreen Farhana, Rafaat Choudhury, Mohammad Jamal Uddin, Ummul Khair Alam, Md. Nazmul Hassan Refat, Sadia Sobhan, Kamrun Nahar, Irfan Nowroze Noor, Md. Noor Ashad-Uz-Zaman, Fatima Nasreen, Mohammad Meshbahur Rahman, Fahmida Khanam   +17 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Democracia, expertise e burocracia: relações entre política, técnica e participação

Ciências Sociais Unisinos, 2013
This article provides a theoretical discussion concerning new models of democratic governance, focusing on the relationship between democracy, expertise and bureaucracy, especially with respect to connections between public administration, technical ...
Frank de Paula Ribeiro
doaj  

Aspects of Public and Private Sociodynamics in the Special Education Policy in the State of Espírito Santo

Fineduca, 2020
In this article, we discuss aspects of the political and social purposes related to the contracting of private Specialized Educational Service, made by the state of Espírito Santo, Brazil.
Gildásio Macedo de Oliveira, Reginaldo Célio Sobrinho   +1 more
doaj