Results 81 to 90 of about 182,811,015 (279)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Administration. Journal of the Institute of Public Administration of Ireland. 1980. Vol 28. No 4.

, 1980
Administration is published four times a year. It is the journal of the Institute of Public Administration Ireland. The views expressed in it are the views of the contributors, and not necessarily those of the Institute.
Litton, Frank, Institute of Public Administration (IPA)   +1 more
core  

The logic of public–private partnerships : the enduring interdependency of politics and markets

, 2020
This book advances a comprehensive and pragmatic understanding of the public-private partnership (PPP) arrangement pertaining to long-term infrastructure contracts.
Kwa, Kai Xiang, Kim, Soojin
core   +1 more source

The Field of Social Regulation: How the State Creates a Profession

Professions and Professionalism, 2013
This article describes the process of professionalisation in the field of social control in Sweden. The aim is to analyse how the state by legislation created the profession of social workers for local social services and thus for social control by ...
Kerstin Svensson, Karsten Åström
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Law, Social Norms and Welfare as Means of Public Administration: Case Study of Mahalla Institutions in Uzbekistan [Elektronisk resurs]

, 2011
Despite numerous challenges, since its independence, Uzbekistan, with the exception of the May 2005 Andijan events, has enjoyed extraordinary political stability and not recorded any considerable cases of interethnic or interfaith conflict, regime change
Urinboyev, Rustamjon,, Lund University.
core   +1 more source

What Makes Citizens Satisfied? The Influence of Perceived Responsiveness of Local Administration on Satisfaction with Public Administration [PDF]

, 2017
. There is no other institution that people regularly have so much direct contact with as public administration, although people have different experiences with public administration.
RÖLLE, Daniel; German University of Administration Research Speyer
core   +1 more source

Assessing U.S. public perceptions of global warming using social survey and climate data

MethodsX
This paper presents a methodological approach for assessing the relationship between weather patterns, regional climate trends, and public perceptions of global warming in the United States with control of socioeconomic, political, and ideological ...
Xiaoxiao Wei, Eve Bohnett, Li An
doaj   +1 more source