Results 71 to 80 of about 2,600,869 (337)

Maximising social interactions and effectiveness within distance learning courses : cases from construction [PDF]

, 2009
Advanced Internet technologies have revolutionised the delivery of distance learning education. As a result, the physical proximity between learners and the learning providers has become less important.
Goulding, JS, Ingirige, MJB
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Public trust in local government in Somalia: effect of citizen participation and perceived local government performance

Cogent Social Sciences
Citizen participation is vital for enhancing trust in local government by ensuring citizens’ voices are heard in decision-making processes. However, most studies focus on central government trust, with limited research in the African context.
Ahmed-Nor Mohamed Abdi, Nurulhasanah Binti Abdul Rahman   +1 more
doaj   +1 more source

Coping in the Covid-19 pandemia: how different resources and strategies can be risk or protective factors to mental health in the Brazilian population

Health Psychology and Behavioral Medicine, 2021
Objective The present study's objective was to investigate the pandemic's impact on mental health and identify variables that can increase or decrease the chances of stress, anxiety, and depression, in both a sample with and one without self-reported ...
Fernanda de Oliveira Ferreira, Júlia Beatriz Lopes-Silva, Gustavo Marcelino Siquara, Edi Cristina Manfroi, Patrícia Martins de Freitas   +4 more
doaj   +1 more source

Information Flow in Social Groups

, 2003
We present a study of information flow that takes into account the observation that an item relevant to one person is more likely to be of interest to individuals in the same social circle than those outside of it.
Adamic, Bernardo A. Huberman, Dezso, Ebel, Eguiluz, Fang Wu, Feld, Joshua R. Tyler, Lada A. Adamic, Newman, Newman, Newman, Newman, Pastor-Satorras, Touhey, Vazquez, Wellman   +16 more
core   +1 more source

Learning in virtual worlds : Using communities of practice to explain how people learn from play [PDF]

, 2009
Although there is interest in the educational potential of online multiplayer games and virtual worlds, there is still little evidence to explain specifically what and how people learn from these environments. This paper addresses this issue by exploring
Carr, Charmaz, De Freitas, DfES-Department for Education and Skills, Gee, Glaser, Haythornthwaite, Malone, McFarlane, Mitchell, Squire, Willging   +11 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Spread of Social Distancing

SSRN Electronic Journal, 2020
We find that social distancing is affected by the policies set in neighboring counties, even after controlling for confirmed COVID cases and weather. A stay-at-home order in a neighboring county reduces social distancing by more than half as much as implementing an order in that county.
Cook, Jonathan, Newberger, Noah, Smalling, Sami   +2 more
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Labor, health, social work and the middle classes: Do Spanish youth have to jeopardize their health to find a job?

Social Work and Society, 2016
In the sphere of the European Union, especially in countries of southern Europe, the economic crisis and the redefining of welfare state benefits have led to a scenario in which many young people encounter major difficulties in attaining and/or ...
Antonio López-Peláez
doaj