Results 81 to 90 of about 2,609,776 (286)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Climate Change Impacts and Adaptation to Flow of Swat River and Glaciers in Hindu Kush Ranges, Swat District, Pakistan (2003-2013) [PDF]

International Journal of Economic and Environment Geology, 2016
This work aims at the climate change impacts and adaptation to surface flow of Swat river and glacier resources in Swat river catchments area, Hindu Kush ranges, Northwest Pakistan.
Saifullah Khan, Mahmood-Ul-Hasan
doaj  

Employer and Employee Obligations in Islam: A Comparative Study with Constitutional Provisions of Pakistan

Pakistan Journal of Islamic Research, 2021
Labour market of Muslim world including Pakistan is characterized with lower level of productivity resulting from job dissatisfaction, and undisciplined work environment.
Shahzadah Fahed Qureshi, Muhammad Mudassar   +1 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The Hedges Used by Ronnie Miller and Steve Miller During Summer Holiday in the Last Song Movie [PDF]

, 2013
This study discussed the types and functions of hedges also some changes of hedges perceived in the using of hedges related to social distance. The Last Song by Nicholas Sparks, were used as the source of data and the data of this study were 16 scenes ...
Mardijono, J. J. (Josefa), Unola, R. (Reinzka)   +1 more
core  

Urban and Rural Environments and Their Implications for Older Adults’ Adaptation to Heat Waves: A Systematic Review

Land
The aim of this study is to synthesise the scientific evidence on the implications of urban and rural environments on older adults’ adaptation strategies to heatwaves. Methods: The methodology follows PRISMA guidelines, which involves a systematic search
Pablo De Gea Grela, Diego Sánchez-González, Lorena Patricia Gallardo Peralta   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Identity and Social Distance in Friendship Formation [PDF]

We analyze a network formation model where agents belong to different communities. Both individual benefits and costs depend on direct as well as indirect connections.
de Marti, Joan, Zenou, Yves
core  

Innovation orientation and firms’ financial performance: The moderating role of new product development

Cogent Business & Management
Previous studies on the relationship between innovation orientation and firms’ financial performance have churned out conflicting results. These contradictions motivated this study.
Justice Boateng Dankwah, Sayibu Ibrahim Nnindini, Zakari Bukari   +2 more
doaj   +1 more source