Results 71 to 80 of about 402,215 (252)
Cogent Business & ManagementPrevious studies on the relationship between innovation orientation and firms’ financial performance have churned out conflicting results. These contradictions motivated this study.
Justice Boateng Dankwah +2 more
doaj +1 more source
Climate Change Impacts and Adaptation to Flow of Swat River and Glaciers in Hindu Kush Ranges, Swat District, Pakistan (2003-2013) [PDF]
International Journal of Economic and Environment Geology, 2016 This work aims at the climate change impacts and adaptation to surface flow of Swat river and glacier resources in Swat river catchments area, Hindu Kush ranges, Northwest Pakistan.
Saifullah Khan, Mahmood-Ul-Hasan
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Pakistan Journal of Islamic Research, 2021 Labour market of Muslim world including Pakistan is characterized with lower level of productivity resulting from job dissatisfaction, and undisciplined work environment.
Shahzadah Fahed Qureshi +1 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
EMOTIONAL MODUS OF POLITICAL COMMUNICATION
Дискурс, 2016 The article is devoted to the analytical potential of the "negative communication" concept in sociological and political studies. The basic idea is that the emotional component of social action reveals structural and dynamic problems of any communicative
N. V. Kazarinova, A. M. Ogorodnova
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source