Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
The Role of the West in Evolving World Order, and Russian Politics
Сравнительная политика, 2016 Coexistence of structurally different modernities with various historical backgrounds and systemic/structural organizations leads to the coexistence of different traditional and new actors within the same spatial-temporal continuum of international ...
A. D. Voskressenski
doaj +1 more source
The Coherence Problem: Mapping the Theory and Delivery of Infrastructure Resilience Across Concept, Form, Function, and Experienced Value [PDF]
, 2015 In this contribution we explore the interface between the functional characteristics of infrastructures as artefacts and social need supplier. Specifically we are concerned with the ways in which infrastructure performance measures are articulated and ...
Jeffrey, P., Smith, H.
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Transregional and Regional Projects in “Post-Western” International Reality
Сравнительная политика, 2017 The article focuses on the theoretical and practical explanations of political and economic processes in the “post-Western” international reality. Proceeding from the assumptions of the complex system theory, the authors prove the necessity to use ...
Alexei D. Voskressenski +2 more
doaj +1 more source
Economic development as design: Insight and guidance through the PSI framework [PDF]
, 2017 Economic development is aimed at improving the lives of people in the developing world, and needs to be carried out with design at its heart, but this has often not been the case.
Eckert, Claudia +3 more
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A Multivocal Literature Review on Growing Social Engineering Based Cyber-Attacks/Threats During the COVID-19 Pandemic: Challenges and Prospective Solutions. [PDF]
IEEE Access, 2021 Hijji M, Alam G.
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Distinguishing Reality from AI: Approaches for Detecting Synthetic Content
ComputersThe advancement of artificial intelligence (AI) technologies, including generative pre-trained transformers (GPTs) and generative models for text, image, audio, and video creation, has revolutionized content generation, creating unprecedented ...
David Ghiurău, Daniela Elena Popescu
doaj +1 more source
Salford postgraduate annual research conference (SPARC) 2012 proceedings [PDF]
, 2013 These proceedings bring together a selection of papers from the 2012 Salford Postgraduate Annual Research Conference (SPARC). They reflect the breadth and diversity of research interests showcased at the conference, at which over 130 researchers from ...
Ahanchian, N +20 more
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