Results 131 to 140 of about 391,045 (303)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Cyber-physical-social systems and constructs in electric power engineering
, 2016 Cyber-physical-social systems (CPSS) integrate computing, physical assets and human networks. Divided into four application areas to the electric grid, this book describes state-of-the-art CPSS in electric power systems, including detailed approaches on ...
Suryanarayanan, Siddharth +2 more
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 2018 Turhan, Cigdem/0000-0002-6595-7095For a number of years, the effects of incorporating social media into education systems has invoked the interest of researchers, academicians and students.
Turhan, Cigdem, Akman, Ibrahim
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Advances in management engineering
, 2017 This book deals with research in open challenges in Management Engineering in the 21st century, as well as selected opportunities and solutions to remedy them.
Hernández, Cesáreo
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Engineering Agent-Based Social Simulations : An Introduction
, 2015 This special section on "Engineering Agent-Based Social Simulations" aims to represent the current state of the art in using Software Engineering (SE) methods in ABSS.
Siebers, Peer-Olaf, Davidsson, Paul
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
American Utopia and Social Engineering in Literature, Social Thought, and Political History
The United States today is afflicted with political alienation, militarized violence, institutionalized poverty, and social agony. Worst of all, perhaps, it is afflicted with chronic and acute ahistoricism.
Swirski, Peter.
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