Results 71 to 80 of about 2,195,820 (278)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Deepfake-Driven Social Engineering: Threats, Detection Techniques, and Defensive Strategies in Corporate Environments

open access: yesJournal of Cybersecurity and Privacy
The evolution of deepfake technology has the potential to reshape the threat landscape in corporate environments by enabling highly convincing digital impersonations.
Kristoffer Torngaard Pedersen   +5 more
doaj   +1 more source

Can a five minute, three question survey foretell first-year engineering student performance and retention? [PDF]

open access: yes, 2016
This research paper examines first-year student performance and retention within engineering. A considerable body of literature has reported factors influencing performance and retention, including high school GPA and SAT scores,1,2,3 gender,4 self ...
Gratiano, Stephanie M., Palm, William J.
core   +1 more source

Formalising responsibility modelling for automatic analysis [PDF]

open access: yes, 2015
Modelling the structure of social-technical systems as a basis for informing software system design is a difficult compromise. Formal methods struggle to capture the scale and complexity of the heterogeneous organisations that use technical systems ...
Simpson, Robert, Storer, Tim
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Food as Experience A Design and Evaluation Methodology [PDF]

open access: yes, 2009
This research, conducted for Frito Lay-North America, Inc, demonstrates how new product designs, package designs, concepts, and prototypes can be created based on the social, emotional, cognitive, and sensory information gathered through a combined ...
Baer, Roger   +3 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Social Engineering [PDF]

open access: yesEngineering & Technology Reference, 2014
Umesh Hodeghatta Rao, Umesha Nayak
  +6 more sources

SoK: Grouping Spam and Phishing Email Threats for Smarter Security

open access: yesIEEE Access
Emails are a vital form of communication, owing to their open nature, which allows any individual to send emails to anyone else without centralized monitoring.
Tarini Saka, Kami Vaniea, Nadin Kokciyan
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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