Results 71 to 80 of about 2,209,260 (308)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Deepfake-Driven Social Engineering: Threats, Detection Techniques, and Defensive Strategies in Corporate Environments

Journal of Cybersecurity and Privacy
The evolution of deepfake technology has the potential to reshape the threat landscape in corporate environments by enabling highly convincing digital impersonations.
Kristoffer Torngaard Pedersen, Lauritz Pepke, Tobias Stærmose, Maria Papaioannou, Gaurav Choudhary, Nicola Dragoni   +5 more
doaj   +1 more source

Semantic Network Analysis of Ontologies [PDF]

, 2011
A key argument for modeling knowledge in ontologies is the easy re-use and re-engineering of the knowledge. However, current ontology engineering tools provide only basic functionalities for analyzing ontologies.
Hoser, Bettina, Hotho, Andreas, Jäschke, Robert, Schmitz, Christoph, Stumme, Gerd   +4 more
core  

An ontology co-design method for the co-creation of a continuous care ontology [PDF]

, 2014
Ontology engineering methodologies tend to emphasize the role of the knowledge engineer or require a very active role of domain experts. In this paper, a participatory ontology engineering method is described that holds the middle ground between these ...
Ackaert, Ann, Bleumers, Lizzy, De Turck, Filip, De Zutter, Saar, Duysburgh, Pieter, Jacobs, An, Ongenae, Femke, Sulmon, Nicky, Verstichel, Stijn, Verstraete, Mathijs   +9 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Can a five minute, three question survey foretell first-year engineering student performance and retention? [PDF]

, 2016
This research paper examines first-year student performance and retention within engineering. A considerable body of literature has reported factors influencing performance and retention, including high school GPA and SAT scores,1,2,3 gender,4 self ...
Gratiano, Stephanie M., Palm, William J.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Social Engineering [PDF]

Engineering & Technology Reference, 2014
Umesh Hodeghatta Rao, Umesha Nayak
  +6 more sources

SoK: Grouping Spam and Phishing Email Threats for Smarter Security

IEEE Access
Emails are a vital form of communication, owing to their open nature, which allows any individual to send emails to anyone else without centralized monitoring.
Tarini Saka, Kami Vaniea, Nadin Kokciyan
doaj   +1 more source

Language engineering - a champion for European culture [PDF]

, 1996
Language is key to culture. It is a direct cultural medium as well as a means of recording and providing access to non-lingual elements of culture. Language is also fundamental to a sense of cultural identity.
Banus, E., Diver, J., Elio, B., Simpkins, N.   +3 more
core