Results 81 to 90 of about 2,195,820 (278)

Education in values in engineering. Energy for human development and sustainability [PDF]

open access: yes, 2008
nergy is central to achieving th e interrelated econo mic, social, and environmental aims of sustaina ble human development. This pa per relates some UPC efforts to introduce the sustainable energy concept in its engineering curricula.
Velo García, Enrique
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Science led vs design led teaching approaches in materials science and engineering for aeronautical engineering students [PDF]

open access: yes, 2013
A comparison on teaching styles has been conducted by analysing behavioural, cognitive, developmental, social cognitive and constructivist perspectives of 26 students (higher engineering apprentices).
Inam, Fawad
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The fragmented Lok Sabha: a case for electoral engineering [PDF]

open access: yes, 2009
Where there are numerous small political parties, as in India, the electoral system neither reflects the true views and opinions on important social and economic issues nor does it incorporate “social inclusiveness” .
Dutta, Bhaskar
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Climate Catastrophe and Stanley Milgram’s Electric Shock “Obedience” Experiments: An Uncanny Analogy

open access: yesSocial Sciences, 2019
Awareness of impending climate catastrophe has greatly increased over the last 30 years. Increasing awareness, however, has not translated into decreasing but instead increasing greenhouse gas emissions.
Nestar Russell, Annette Bolton
doaj   +1 more source

Producing Children\u27s Toys through 3-D Printing: A Multidisciplinary Approach [PDF]

open access: yes, 2013
One of the things that first attracted me to VCU was the opportunity for interdisciplinary discussions and interactions. I saw HSURP as a way to push my boundaries and interact with peers from different disciplines.
Rifareal, Rebekah
core   +1 more source

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