Results 111 to 120 of about 4,951,721 (322)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

What Strategies do Companies use to Transform Employees into Social Media Advocates? [PDF]

open access: yes, 2015
There is an overwhelming consensus among researchers that employees have the potential to become excellent social ambassadors for their company. Readers of social media sites believe employees to be credible representatives of their organization, and ...
Drori, Elad
core   +1 more source

Examining the impacts of urban, work and social environments on residents’ subjective wellbeing: a cross-regional analysis in China

open access: yesFrontiers in Environmental Science
Introduction: Urbanization has affected the quality of the living environments. It is important to improve residents’ living environments and promote their happiness.Methods: We use a national and representative dataset targeting the labor force in China,
Zhou Fang, Yuxin Liao, Chang Ma, Rong Wu
doaj   +1 more source

Social status, environment, and atherosclerosis in cynomolgus monkeys. [PDF]

open access: bronze, 1982
Jay R. Kaplan   +4 more
openalex   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Social Capital Capacity as Prediction of Dengue Control [PDF]

open access: yes, 2016
The program of elimination of mosquito breeding places is still low since there is no public participation effort in vector control. Social capital is key factor for sustaining any health programs implemented.
Kartono, D. T. (Drajat)   +3 more
core  

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

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