Results 131 to 140 of about 18,481,063 (389)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Effect of Vigor and Affective Commitment on the Performance of Women Student Entrepreneurs: the Moderating Role of the Social and University Environment

Management Letters/Cuadernos de Gestión
This study aims to analyze the performance of university women in active entrepreneurship from the perspective of cognitive variables, such as vigor and affective commitment, and contextual variables, such as the social and uni-versity environments.
Ana Gabriela Víquez-Paniagua, Juan Carlos Leiva, Ronald Mora-Esquivel   +2 more
doaj   +1 more source

The future of information systems-using social systems to create protocols for the virtual environment (systems analysis through social analysis) [PDF]

, 1996
Information is the medium for communication, power-play, politics, and the building block for knowledge systems. It is associated with social interaction, and can be mediated by technology use. The paper argues that the key to understanding the impact of
Conkar, T, Kimble, C
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The bodily other and everyday experience of the lived urban world [PDF]

, 2016
This article explores the relationship between the bodily presence of other humans in the lived urban world and the experience of everyday architecture.
Bader, Oren, Peri Bader, Aya
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Neighborhood social environment and mental health of older adults in China: the mediating role of subjective well-being and the moderating role of green space

Frontiers in Public Health
IntroductionWith the continuous development of the global aging trend, the mental health of older adults has been a concern by the world. The living space of older adults is limited due to the decline of their activity function. Neighborhood environment,
Taizhi Lin, Qianhui Wang, Zixuan Tan, Wen Zuo, Rong Wu   +4 more
doaj   +1 more source

Exploring the Impact of Built Environment Attributes on Social Followings Using Social Media Data and Deep Learning [PDF]

, 2022
Yiwen Tang, Jiaxin Zhang, Runjiao Liu, Yunqin Li   +3 more
openalex   +1 more source

Social Environment Design

Artificial Intelligence (AI) holds promise as a technology that can be used to improve government and economic policy-making. This paper proposes a new research agenda towards this end by introducing Social Environment Design, a general framework for the use of AI for automated policy-making that connects with the Reinforcement Learning, EconCS, and ...
Zhang, Edwin, Zhao, Sadie, Wang, Tonghan, Hossain, Safwan, Gasztowtt, Henry, Zheng, Stephan, Parkes, David C., Tambe, Milind, Chen, Yiling   +8 more
openaire   +2 more sources