Results 41 to 50 of about 17,528,261 (299)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gone girl: Richardson's ground squirrel offspring and neighbours are resilient to female removal [PDF]

open access: yesRoyal Society Open Science, 2019
Within matrilineal societies, the presence of mothers and female kin can greatly enhance survival and reproductive success owing to kin-biased alarm calling, cooperation in territory defence, protection from infanticidal conspecifics, joint care of young
Angela R. Freeman   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Social Value Toolkit [PDF]

open access: yes, 2021
This Social Value Toolkit has been developed principally to help guide heritage practitioners working within institutional contexts who need to understand the social values associated with the historic environment as part of their work. Social value has
Robson, Elizabeth
core  

The Social and Cultural Adaptation of Immigrants Within the Context of Integration into Russian Society

open access: yesСоциологическая наука и социальная практика, 2019
The paper covers the issue of the social and cultural adaptation and integration of immigrants into Russian society. It is based on sociological studies that were conducted in Moscow, Penza, and Tambov.
Asya V. Voropaeva
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Kansas environment, 1981

open access: yes, 1981
This internet resource combines newsletters issued throughout the year.
Kansas. Division of Environment
core   +1 more source

Healing in a Greener Future: Sustainable Pathways for Dermatology

open access: yesJEADV Clinical Practice
Background Sustainable dermatology requires balancing patient outcomes with environmental stewardship and social responsibility. Objectives To examine environmental impacts related to skin health and emerging solutions. Methods Targeted literature review.
Henry W. Lim
doaj   +1 more source

Core influencing factors of group blood donation in Beijing

open access: yesFrontiers in Public Health
IntroductionGroup blood donation is a significant component of the urban blood supply. The imperative to enhance the management and utilization of this workforce, to increase the organizational mobilization capabilities of various blood donation entities,
Rui Liu
doaj   +1 more source

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