Results 61 to 70 of about 5,661,520 (295)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

How humans behave and evaluate a social robot in real-environment settings [PDF]

open access: yes, 2010
Behavioral analysis has proven to be an important method to study human-robot interaction in real-life environments providing highly relevant insights for developing new theoretical and practical models of appropriate social robot design.
Dijk, Betsy van   +4 more
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

ECONOMY AND SOCIAL ENVIRONMENT [PDF]

open access: yes
Market reforms in the post-socialist countries have brought into sharp focus the problem of interconnection and interaction between the economy and the social environment. The economy is inseparable from politics and the operation of the political system,
Oleg BOGOMOLOV
core  

Social capital and burnout among mental healthcare providers [PDF]

open access: yes, 2018
Background: Provider burnout is a critical problem in mental health services. Contributing factors have been explicated across three domains: personal, job and organizational characteristics.
Eliacin, Johanne   +5 more
core   +1 more source

Family, friends and taxi drivers in hybrid networks. Integrating the immediate social environment into the Spiral of Silence Theory

open access: yesStudies in Communication Sciences, 2022
The relative neglect of the immediate social environment is one of the best-known criticisms of the Spiral of Silence Theory (SoS). Due to massive changes in communication technology, especially the advent of social media, the immediate social ...
Christiane Eilders   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Study on Behavioral Traits of Library and Information Science Students in South India

open access: yesJournal of Information Science Theory and Practice, 2013
Human behaviour normally depends on the environment of the incident and the time of its occurrence. The behaviour of people depends on many factors and these behaviour traits are an important aspect in the Library and Information Science (LIS) field ...
Baskaran, S.   +2 more
doaj  

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