Results 101 to 110 of about 504,419 (304)

Neoliberalism, Inequalities and Social Movements in the European Union [PDF]

open access: yes, 2020
The paper discusses the growing literature on the interrelations between neoliberal policy and rising inequalities in the European Union, and their impact to the growing social movements.
Dokmanović, Mirjana, Cvetićanin, Neven
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Reinventing Social Solidarity Across Europe

open access: yes, 2011
As Europe's public realms face upheaval, this is the first book to identify how social solidarity is being re-invented from below and redefined from above.
Ellison, Marion
core  

Social Citizenship and Institution Building: EU-Enlargement and the Restructuring of Welfare States in East Central Europe, CES Germany & Europe Working Paper no. 01.2, April 2001 [PDF]

open access: yes, 2001
With the EU-enlargement process well underway, this paper focuses on social citizenship as a conceptual frame for analyzing the restructuring of social institutions in applicant countries in East Central Europe. So far, comparative welfare state analysis
Lemke, Christian, Lemke, Christiane.
core  

Digital First Primary Care for those with multiple long-term conditions: a rapid review of the views of stakeholders

open access: yesHealth and Social Care Delivery Research
Background General practices are facing challenges such as rising patient demand and difficulties recruiting and retaining general practitioners. Greater use of digital technology has been advocated as a way of mitigating some of these challenges and ...
Jennifer Newbould   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Social inclusion for young people: breaking down the barriers

open access: yes, 2007
Social exclusion, the polarisation of the types of chances life offers to different groups of young people, is increasing, it is spatially concentrated in some regions and neighbourhoods and is arguably linked to social class.
Boetzelen, Philipp   +3 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Towards a European pillar of social rights : upgrading the EU social 'acquis'

open access: yes, 2017
Publication Date: 11 January 2017The European Commission has recently launched a ‘European Pillar of Social Rights’. The Pillar consists of a broad range of social principles. The European Union’s social acquis, comprised of the EU Charter of Fundamental
KILPATRICK, Claire   +4 more
core  

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