Results 131 to 140 of about 2,318,051 (294)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Social Organization Is Associated With Relaxed Selection on Worker Genes in Highly Polygyne Ants
Ecology and EvolutionAnts display a diversity of social structures reflected by differences in caste, nest, and colony organization. Previous research has shown that highly eusocial insects (Hymenoptera) exhibit genome‐wide signatures of relaxed selection due to their ...
Kailey Ferger, Neil D. Tsutsui
doaj +1 more source
Stemming the Flow: Information, Infection, and Social Evolution. [PDF]
Trends Ecol Evol, 2020 Romano V, MacIntosh AJJ, Sueur C.
europepmc +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Ecology and EvolutionIn social mammals, dominance status and tenure length are often important determinants of male reproductive success. Nevertheless, alternative strategies, such as extra‐pair mating, and the active role of females in securing reproductive benefits can ...
Fan Wu +11 more
doaj +1 more source
Human Social Evolution: Self-Domestication or Self-Control? [PDF]
Front Psychol, 2020 Shilton D, Breski M, Dor D, Jablonka E.
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The Price equation and the unity of social evolution theory. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2020 Lehtonen J.
europepmc +1 more source