Results 231 to 240 of about 2,318,051 (294)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Global research trends on depression-related stigma in the 21st century: a bibliometric analysis. [PDF]

Glob Health Action
Zhamaliyeva L, Batyrova A, Ablakimova N, Veklenko G, Malsova B, Tautanova A, Grjibovski AM.   +6 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Generalized Galton's boards explain social phenomena via statistical physics. [PDF]

Sci Rep
Auricchio G, Ghiotto M, Gualandi S, Toscani G.   +3 more
europepmc   +1 more source

The key role of cheaters in the persistence of cooperation. [PDF]

BMC Biol
Babajanyan SG, Wolf YI, Koonin EV, Rochman ND.   +3 more
europepmc   +1 more source

Investigating the role of the left inferior frontal gyrus in language evolution: insights from comparative neuroscience. [PDF]

Front Hum Neurosci
Zhang J, Song Y, Tan LH.
europepmc   +1 more source

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Social Evolution

2015
"It is a mater of dispute how far back evolutionary explanations of social order should be traced. Evolutionary ideas certainly appear in the work of the ancient Greek philosophers, but it seems reasonable to identify the origins of modern evolutionary thinking in the eighteenth century natural histories of civil society such as Rousseau’s Discourse ...
Gaus, Gerald, Thrasher, John
openaire   +2 more sources