Results 241 to 250 of about 14,672,329 (357)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Phylogenomic Evidence Overturns Current Conceptions of Social Evolution in Wasps (Vespidae). [PDF]

Mol Biol Evol, 2018
Piekarski PK, Carpenter JM, Lemmon AR, Lemmon AR, Moriarty Lemmon E, Sharanowski BJ.   +5 more
europepmc   +1 more source

Development of industry in the context of social consciousness evolution: analytical approach

Anastasia Peshkova, Alexei B. Galkin
openalex   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Building a new research framework for social evolution: intralocus caste antagonism. [PDF]

Biol Rev Camb Philos Soc, 2018
Pennell TM, Holman L, Morrow EH, Field J.   +3 more
europepmc   +1 more source

Leadership Models, Social Selection, and the Evolution of Western Civilization

Andriy Nosalsky
openalex   +1 more source

Dynamic evolution of alpine grassland social-ecological resilience and its characteristics based on the “components-attributes-capacities” framework: a case study of the Qinghai-Tibet Plateau [PDF]

tianlong guo, Ling Zhao, Jinmeng Yang, Yin Tang   +3 more
openalex   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

社会动力学论:社会势能的概念、机制与历史形态 —— 一种解释社会运动与文明演化的双层动力学框架 Social Dynamics Theory: The Concept, Mechanism, and Historical Forms of Social Potential Energy —— A DualLayer Dynamics Framework for Explaining Social Movement and Civilizational Evolution

中杰君 王
openalex   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source