Results 81 to 90 of about 340,184 (306)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Power, Dependence and Social Exchange

open access: yes, 2017
Power is a primary dimension of inequality in society and an important determinant of life chances. It has been a major focus of social and political theory since the time of Hobbes, Machiavelli, Marx and Weber, among others.
Cook, KS, Gerbasi, AM, Cheshire, C
core  

Exchange Club of Fargo Records, 1946-2001 [PDF]

open access: yes, 2018
The First Exchange Club of Fargo started in the 1920?s but did not survive the great depression and members left or joined the Fargo Lions Club. The second Exchange Club of Fargo was charted in 1946 with 73 members.
Exchange Club of Fargo
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Gift Exchange in the Workplace: Money or Attention? [PDF]

open access: yes
We develop a model of manager-employee relationships where employees care more for their manager when they are more convinced that their manager cares for them.
Dur, Robert
core  

Social Support as Social Exchange: Exchange Structure and Social Solidarity in Online Support Groups [PDF]

open access: yes, 2022
Adopting the framework of social exchange in researching supportive communication, this work proposes the concept of support exchange. This dissertation defines support exchange and discusses how support exchange is similar to and different from ...
Kim, Chelsea
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Unpacking the Black Box of the Training-Performance Relationship: Evidence from Philippine Call Centers

open access: yesM@n@gement
This study analyzes the relationship between training and development (T&D) and individual performance. Drawing insights from human capital theory and social exchange theory, we hypothesize that the relationship between employee T&D perceptions and role ...
Kristine Tamayo-Verleene   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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