Results 151 to 160 of about 1,821,326 (334)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Desigualdad territorial y exclusión social.

Vivienda y Ciudad, 2019
La desigualdad es un fenómeno complejo donde interactúan dimensiones económicas, políticas, sociales, culturales, ambientales, territoriales y cognitivas. En ese marco de ideas, analizamos las expresiones de las desigualdades territoriales que en ciudad
Magela Cabrera Arias
doaj  

Group Belongingness and Procedural Justice: Social Inclusion and Exclusion by Peers Affects the Psychology of Voice.

, 2004
Jan‐Willem van Prooijen, Kees van den Bos, Henk Wilke   +2 more
openalex   +2 more sources

The patterns and causes of social exclusion in Luxembourg [PDF]

The paper investigates the forms and determinants of social exclusion in Luxembourg and addresses both conceptual and empirical issues. We therefore examine the following issues: what definition of social exclusion is more appropriate for Luxembourg, if ...
Raileanu Szeles, Monica
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Processing of social exclusion in a strict hierarchy. [PDF]

PLoS One
Niedeggen M, Kerschreiter R.
europepmc   +1 more source

Fragmenting Work, Fragmented Regulation: The Contract of Employment as a Driver of Social Exclusion [PDF]

, 2015
Einat Albin, Jeremias Adams‐Prassl
openalex  

CHILD POVERTY IN NORTHERN IRELAND: RESULTS FROM THE POVERTY AND SOCIAL EXCLUSION STUDY

, 2014
Michael Tomlinson, Paddy Hillyard, Grace Kelly   +2 more
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Exclusión y conocimiento social Exclusion and social knowledge

Sociologias, 2006
Raquel Sosa Elízaga
doaj   +1 more source