Results 211 to 220 of about 19,778,298 (257)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Cumulative effect of multiple health and social factors on adolescent mental well-being: a cross-sectional study in Catalonia. [PDF]

Child Adolesc Ment Health
Robles-Muñoz M, Bosque-Prous M, Folch C, González-Casals H, Drou-Roget G, Torrado-Cortés C, Muntaner C, Espelt A.   +7 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Explainable machine learning of PROGRESS-Plus social factors predicts cognitive trajectories after traumatic brain injury. [PDF]

Sci Rep
Xu J, Shaikh U, Tylinski Sant'Ana T, Mollayeva T.   +3 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Memoria de actividades del Consejo Económico y Social de Aragón.: 2011 [PDF]

, 2011
Consejo Económico y Social de Aragón., Consejo Económico y Social de Aragón   +1 more
core  

Matching on health status to estimate the effects of outpatient care and social factors in patients with COPD: a Norwegian registry‑based study. [PDF]

BMC Health Serv Res
Moger TA, Holte JH, Amundsen O, Haavaag SB, Edvardsen A, Bragstad LK, Hellesø R, Vøllestad NK, Tjerbo T.   +8 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Social factors contributing to the development of chronic low back pain: a scoping review. [PDF]

BMC Musculoskelet Disord
Sonjon Y, Gonthier A, Lépingle C, Van der Henst JB, Reilly KT, Chabanat E.   +5 more
europepmc   +1 more source