Results 71 to 80 of about 5,387,829 (355)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
An Outline of the Changes in Slovak Literary Criticism from the Mid-1960s to the Early 1970s. (3th Part) [PDF]
Slovenska Literatura, 2015 This literary history paper is concerned with the changes of Slovak literary criticism over a certain period of time. It reconstructs the process of the criticism becoming temporarily emancipated, i.e.
Vladimír Barborík
doaj
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Scaling New Heights: How to Spot Small Successes in the Public Sector and Make Them Big [PDF]
, 2010 Examines barriers to bringing innovations to scale in the social sector and recommends developing a market for social outcomes, designing funding models that encourage scaling, shaping the field of knowledge about what works, and investing in ...
Geoff Mulgan, Jitinder Kohli
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
A Field Study of Social Learning [PDF]
We present a field study of social learning. The setting is a pair of adjacent fast food restaurants serving very similar cuisine whose main clientele are the students at a nearby major university.
Arthur Fishman, Uri Gneezy
core
Towards Psychometrics-based Friend Recommendations in Social Networking Services
, 2017 Two of the defining elements of Social Networking Services are the social profile, containing information about the user, and the social graph, containing information about the connections between users.
Beierle, Felix +3 more
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
European Papers, 2016 (Series Information) European Papers - A Journal on Law and Integration, 2016 1(1), 323-325 | European Forum Highlight of 16 April 2016 | (Abstract) This Opinion considers whether requiring to economically inactive EU citizens who reside in the UK to ...
Sara Benedi Lahuerta
doaj +1 more source