Results 51 to 60 of about 1,710,604 (308)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
GASTO SOCIAL FEDERAL: dimensionamento e análise para o período 1995-2002
Revista de Políticas Públicas, 2005 Measurement and analysis of the federal government expenditure in social areas to the long one of the period understood between 1995-2002. The results of this work show an evolution of the GSF with small macroeconomic priority.
Jorge Abrahão de Castro
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Duopoly innovation with monopoly debater [PDF]
Revista Brasileira de Gestão De Negócios, 2017 Purpose – This paper highlights the interaction between innovation and financial structure under duopoly with a monopoly debater. Design/methodology/approach – By game-theory approaches, we characterize effects of debt levels on innovative investment
You-hua CHEN, Pu-yan NIE, Ji-bo Huang
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Social Finance and Social Enterprises: a New Frontier for Development in Indonesia [PDF]
, 2017 The number of social finances and social enterprises are steadily growing in Indonesia. However, there is yet to be comprehensive research in this context.
Dea, V. (Valencia) +2 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Productivity of Schools and Other Local Public Goods Providers [PDF]
I construct an agency model of local public goods producers with special reference to public schools. The model assumes that households make Tiebout choices among jurisdictions, but it has more realistic assumptions about information and the cost of ...
Caroline M. Hoxby
core
Contagious Synchronization and Endogenous Network Formation in Financial Networks [PDF]
, 2014 When banks choose similar investment strategies the financial system becomes vulnerable to common shocks. We model a simple financial system in which banks decide about their investment strategy based on a private belief about the state of the world and ...
Aymanns, Christoph, Georg, Co-Pierre
core +2 more sources