Results 51 to 60 of about 1,726,095 (357)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
‘De facto’ responsible innovation in early-stage ventures: the reinforcing role of impact investors
Journal of Responsible InnovationThough much attention has been paid to the intentional adoption of Responsible Innovation (RI), the drivers of de facto RI (responsible innovation framed through organisations' existing practices, independent of RI principles) remain underexplored.
Samuel Applebee, Leid Zejnilovic
doaj +1 more source
A Framework to Use Public-Private Partnership for Smart City Projects [PDF]
, 2013 The concept of Smart City has been emerging as a strategic set of integrated initiatives encompassing infrastructures, technology and digital services for the purpose of enhancing the quality of life of citizens.
Calderini, Mario +3 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Asset pricing models, the labour theory of value and their implications for accounting [PDF]
, 2004 The paper analyses the social components of two theories of central importance to accounting and finance. It shows that modern finance theory is unable to account for value and that although its canon and major assumptions successfully obfuscate real ...
Toms, S.
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
GASTO SOCIAL FEDERAL: dimensionamento e análise para o período 1995-2002
Revista de Políticas Públicas, 2005 Measurement and analysis of the federal government expenditure in social areas to the long one of the period understood between 1995-2002. The results of this work show an evolution of the GSF with small macroeconomic priority.
Jorge Abrahão de Castro
doaj
Willingness to Comply with Corporate Law: An Interdisciplinary Teaching Method in Higher Education [PDF]
, 2018 Using an innovation training project, an interdisciplinary cross-sectional teaching strategy was developed to enhance students’ willingness to comply with the law.
Palos Sánchez, Pedro Ramiro +1 more
core +4 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source