Results 81 to 90 of about 2,065,924 (290)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dangerous liaisons: A social network model for the gender wage gap. [PDF]

We combine stylized facts from social network literature with findings from the literature on the gender wage gap in a formal model. This model is based on employers’ use of social networks in the hiring process in order to assess employee productivity ...
Goos, Maarten, Salomons, A
core   +3 more sources

Speed of Transition, Unemployment Dynamics and Nonemployment Policies: Evidence from the Visegrad Countries [PDF]

In Central and Eastern Europe the restructuring process of large state enterprises had the effect of increasing unemployment. Social policy expenditure, in particular nonemployment policies, grew faster then expected due to the need of financing the ...
Randolph Luca Bruno
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modelling Context Effects in Exit Choice for Building Evacuations

Fire
Understanding exit choice behaviour is essential for optimising safety management strategies in building evacuations. Previous research focused on contextual attributes, such as spatial information, influencing exit choice, often using utility models ...
Dongli Gao, Xuanwen Liang, Qian Chen, Hongpeng Qiu, Eric Wai Ming Lee   +4 more
doaj   +1 more source

Modelling shared space users via rule-based social force model [PDF]

, 2015
The promotion of space sharing in order to raise the quality of community living and safety of street surroundings is increasingly accepted feature of modern urban design. In this context, the development of a shared space simulation tool is essential in
Anvari, B, Bell, MGH, Ochieng, WY, Sivakumar, A   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Characterization of superspreaders movement in a bidirectional corridor using a social force model. [PDF]

Front Public Health, 2023
Kanté DSI, Jebrane A, Hakim A, Boukamel A.   +3 more
europepmc   +1 more source

WOMEN’S LABOR FORCE PARTICIPATION AND THE DYNAMICS OF TRADITION [PDF]

We present a model in which the social norms regarding women’s labor force participation (LFP) differ from the norms concerning men’s. Assuming that these norms depend on past rates of women LFP creates a gradual increase in women LFP.
Moshe Hazan, Yishay D. Maoz
core