Results 61 to 70 of about 2,065,924 (290)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility

, 2014
Myxococcus xanthus is a model organism for studying bacterial social behaviors due to its ability to form complex multi-cellular structures. Knowledge of M.
Balagam, Rajesh, Czerwinski, Fabian, Igoshin, Oleg A., Kaplan, Heidi B., Litwin, Douglas B., Shaevitz, Joshua W., Sun, Mingzhai   +6 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A heterogeneous crowd evacuation model integrating multi-dimensional panic emotion characteristics

Journal of Physics: Complexity
In emergency evacuation scenes, environmental uncertainties and information deficits often trigger panic among individuals, which in turn impairs their ability to make sound judgments and decisions.
Chaoran Zhou, Haijian Wang, Xin Zhang
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Improved Multi-Agent Reinforcement Learning for Path Planning-Based Crowd Simulation

IEEE Access, 2019
The combination of multi-agent technology and reinforcement learning methods has been recognized as an effective way which is used in path planning-based crowd simulation. However, the existing solution is still not satisfactory due to the problem in the
Qingqing Wang, Hong Liu, Kaizhou Gao, Le Zhang   +3 more
doaj   +1 more source

Generalized Opinion Dynamics from Local Optimization Rules [PDF]

, 2014
We study generalizations of the Hegselmann-Krause (HK) model for opinion dynamics, incorporating features and parameters that are natural components of observed social systems.
Chatterjee, Avhishek, Sarwate, Anand D., Vishwanath, Sriram   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Tracking and Simulating Pedestrian Movements at Intersections Using Unmanned Aerial Vehicles

Remote Sensing, 2019
For a city to be livable and walkable is the ultimate goal of future cities. However, conflicts among pedestrians, vehicles, and cyclists at traffic intersections are becoming severe in high-density urban transportation areas, especially in China ...
Jiasong Zhu, Siyuan Chen, Wei Tu, Ke Sun
doaj   +1 more source