Results 171 to 180 of about 5,114,159 (363)

Social-RAG: Retrieving from Group Interactions to Socially Ground AI Generation [PDF]

open access: yesarXiv
AI agents are increasingly tasked with making proactive suggestions in online spaces where groups collaborate, yet risk being unhelpful or even annoying if they fail to match group preferences or behave in socially inappropriate ways. Fortunately, group spaces have a rich history of prior interactions and affordances for social feedback that can ...
arxiv  

Editorial: Creating the Future [PDF]

open access: yes, 2018
Editorial to a special edition of 'Cosmos and History: The Journal of Natural and Social Philosophy': Creating the Future, December ...
Gare, Arran
core  

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1155-1169, April 2025.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park   +8 more
wiley   +1 more source

Trade, urban hinterlands and market integration, 1300-1600: a summing up [PDF]

open access: yes, 2000
Paper given at a conference organised by the Centre for Metropolitan History and supported by the Economic and Social Research Council, 7 July ...
Dyer, Christopher
core  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso   +12 more
wiley   +1 more source

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