Results 81 to 90 of about 12,111,754 (350)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

For neuroscience, social history matters. [PDF]

open access: yesNeuropsychopharmacology, 2023
George A, Padilla-Coreano N, Opendak M.
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Analysis of the Impact of Oil on the Political Structure of Iraq in the Framework of the Rentier State Theory

open access: yesJournal of Arts, Humanities and Social Science
Iraq is a sensitive and geopolitical region in the Middle East from a civilizational point of view, oil, as the most important source of income for the Iraqi government, which provides more than 90% of the annual budget of the government, and this had a ...
Sayeed Ahmad Khalid Sharifi   +1 more
doaj   +1 more source

Between India and the Indies: German mercantile networks, the struggle for the imperial crown and the naming of the New World

open access: yesCulture & History Digital Journal, 2014
In 1507, the excitement over the publication of the Mundus Novus led to the naming of a new continent on the map, a globe and a learned treatise as an appendix to an edition of a work by Ptolemy published in Saint-Dié, Lorraine.
Renate Pieper
doaj   +1 more source

The attitude of the Public Toward Social History Taking in Southern Saudi Arabia. [PDF]

open access: yesPatient Prefer Adherence, 2023
Alkhaldy HY   +8 more
europepmc   +1 more source

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