Results 81 to 90 of about 5,668,569 (360)
, 2016 [Excerpt] This report provides an overview of Social Security financing and benefits under current law. Specifically, the report covers the origins and a brief history of the program; Social Security financing and the status of the trust funds; how ...
Nuschler, Dawn
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Economies of scale and obstacles to land reform, Andalusia 1931-36 [PDF]
, 2006 Proceedings of the Sixth European Social Science History Conference, Amsterdam, 22-25 March 2006 ...
Carmona, Juan, Simpson, James
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 1958 Vastly increased research and a sounder technique in history in the nineteenth century had two influences on the social sciences. When an enthusiasm for the records of history was combined with the evolutionary perspective, it often resulted in the ...
Bloom, Robert L. +6 more
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Editorial: Creating the Future [PDF]
, 2018 Editorial to a special edition of 'Cosmos and History: The Journal of Natural and Social Philosophy': Creating the Future, December ...
Gare, Arran
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Enhancing the Effectiveness of Social Dialogue Articulation in Europe (EESDA) Project No. VS/2017/0434 Comparative policy recommendations on improving social dialogue articulation and effectiveness in Europe [PDF]
, 2019 The history of European social dialogue dates back to the mid-1980s with the Val Duchesse social dialogue initiative by the European Commission. The aim then was to involve social partners in the internal market process.
Akgüç, Mehtap, Baiocco, Sara
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