Results 101 to 110 of about 17,410,214 (348)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

How do People Relate to the Police? A Qualitative Study on Motivational Postures Towards the Police in Chile

open access: yesJournal of Politics in Latin America
How do people position themselves towards the police? We draw on Motivational Postures Theory to analyse the relationship between citizens and the police in Chile.
Luciano Sáez Fuentealba   +4 more
doaj   +1 more source

History of Sexual Violence in Higher Education [PDF]

open access: yes, 2018
In this chapter, we describe the history of sexual violence as it pertains to postsecondary institutions, focusing on social movements, research, and policy, and their implications for higher ...
Jessup-Anger, Jody E.   +2 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Interdisciplinary research of the Neolithic Volga-Kama pottery

open access: yesDocumenta Praehistorica, 2013
In this article, we present a new method of studying Neolithic Volga-Kama pottery, which involves typological and technological analysis and the radiocarbon dating of vessels.
Aleksandr Vybornov, Irina Vasilyeva
doaj   +1 more source

Economies of scale and obstacles to land reform, Andalusia 1931-36 [PDF]

open access: yes, 2006
Proceedings of the Sixth European Social Science History Conference, Amsterdam, 22-25 March 2006 ...
Carmona, Juan, Simpson, James
core   +1 more source

Quality of life in Romanian patients with schizophrenia based on gender, type of schizophrenia, therapeutic approach, and family history [PDF]

open access: yes, 2018
The low quality of life of patients with schizophrenia has been extensively discussed and investigated. Various aspects from gender, socio-demographic profile, and/or type of neuroleptic treatment have been taken into account in describing this condition.
Alexinschi, Ovidiu Eugen   +4 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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