Results 81 to 90 of about 17,410,214 (348)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

A Primer on Social Neuroscience [PDF]

open access: yes, 2010
{Excerpt} Human history is not only social history but also neurobiological history. Throughout most of the 20th century, social and biological explanations were widely viewed as incompatible. However, from the 1990s, the emergence of social neuroscience
Serrat, Olivier
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Mapping Diversity in Social History [PDF]

open access: yes
The paper is an overview of diversity in history, starting as far back as the societies in classical Ancient Europe and traditional non-European societies, where differentiation was basically between the enslaved and free population and the out-of-caste ...
Ercole Sori
core  

The Promise at Hand [PDF]

open access: yes, 1992
Based on a former RWJF vice president's seminar, gives an overview of the history and role of foundations in U.S. society, their uncertain status as social institutions, and their regulatory history.
Terrance Keenan
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A historical analysis of health services in Medan and the tobacco plantation areas of East Sumatra during the Dutch colonial period

open access: yesCogent Arts & Humanities
Medan, formerly known as Deli City, developed in connection with the expansion of Deli tobacco companies in East Sumatra. Historic buildings scattered throughout the city reflect the colonial legacy of the plantation economy, with hospitals among the ...
Wasino Wasino   +4 more
doaj   +1 more source

Critical Sociology and Social History [PDF]

open access: yes
[No abstract][No keywords]
Eric Hobsbawm
core  

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