Results 51 to 60 of about 2,906,069 (317)

Combustion and Society: A Fire-Centred History of Energy Use [PDF]

, 2014
Fire is a force that links everyday human activities to some of the most powerful energetic movements of the Earth. Drawing together the energy-centred social theory of Georges Bataille, the fire-centred environmental history of Stephen Pyne, and the ...
Clark, N, Yusoff, K
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Nonseparable Preferences and Optimal Social Security systems [PDF]

In this paper, we consider economies in which agents are privately informed about their skills, which are evolving stochastically over time. We require agents’ preferences to be weakly separable between the lifetime paths of consumption and labor ...
Borys Grochulski, Narayana Kocherlakota
core   +3 more sources

Practical necessity and the fulfilment of the plan of nature in Kant's idea for a universal history [PDF]

, 2019
I explore the role of practical necessity in Kant’s essay Idea for a Universal History with a Cosmopolitan Aim. This form of necessity arises on the basis of social and interstate antagonism and Kant appeals to it with the aim of avoiding the ...
James, David Neil
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Small scale palm oil producers and supply chains left out from existing certification schemes. [ID781] [PDF]

, 2019
Agricultural history explains most of current palm oil production models (organization of actors including oil palm growers and supply chains). An indigenous non-timber forest product in Central Africa which plant was domesticated and integrated into ...
Durand, Claire, Farago-Szekeres, Tom, Feintrenie, Laurene, Gazull, Laurent, Laumain, Mélanie, Lesage, Colombine, Michel, Isabelle, Pasquis, Richard, Robiglio, Valentina   +8 more
core  

A European perspective on auditory processing disorder-current knowledge and future research focus [PDF]

, 2017
Current notions of \u201chearing impairment,\u201d as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday ...
Bamiou, Doris-Eva, Barajas, Jose, Brechmann, Andr\ue3\ua9, Callimachou, Marina, Deggouj, Na\ue3\uafma, Demanez, Laurent, Grech, Helen, Hedjever, Mladen, Iliadou, Vasiliki, Kiese-Himmel, Christiane, Konukseven, Ozlem, Kuske, Sandra, Martins, Jorge Humberto, Mattsson, Tone Stokkereit, Nickisch, Andreas, Pedersen, Ellen Raben, Ptok, Martin, Santarelli, Rosamaria, Sirimanna, Tony, Sliwinska-Kowalska, Mariola, Thai-Van, Hung, Veraguth, Dorothy, Veuillet, Evelyne   +22 more
core   +6 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source