Results 31 to 40 of about 197,854 (254)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Information and communication technologies, e-Health and homelessness: A bibliometric review
Cogent Psychology, 2019 A bibliometric review was conducted to assess the available scientific knowledge regarding the use of Information and Communication Technologies (ICT) by Individuals Experiencing Homelessness (IEH) and reflect on the existing evidence that ICT use has on
Fran Calvo +2 more
doaj +1 more source
Invited commentary: The long term impact of forced migration during childhood on adult health
SSM: Population Health, 2016 Saarela and Elo (SSM-Population Health; Volume 2, December 2016, Pages 813–823) provide new evidence of early life forced displacement not being adversely associated with adult health. Their study highlights some of the challenges to identifying a causal
Torsten Santavirta
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
BMC Public Health, 2016 Background Despite the importance of adequate, un-crowded housing as a prerequisite for good health, few large cohort studies have explored the health effects of housing conditions. The Social Housing Outcomes Worth (SHOW) Study was established to assess
Michael G. Baker +5 more
doaj +1 more source
Parameters for improvement of the housing quality in social housing dwellings [PDF]
Facta Universitatis. Series: Architecture and Civil Engineering, 2014 Experiences of the countries with developed social housing sector indicate that the role of social housing should not be treated in a limited manner, considered to be just a roof over one’s head, whereby housing quality will be neglected ...
Petković-Grozdanović Nataša +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Belgeo, 2023 While the retreat of state from social housing sector has been a mainstream trend worldwide in the past decades under neoliberalism, the Chinese government returned to its role of social housing provision since the year 2007. This triggers an interesting
Danyang Li
doaj +1 more source
More Social Housing? A Critical Analysis on Social Housing Provision in Spain
Critical Housing Analysis, 2017 Since the 1950s Spain has developed a set of policies aimed at stimulating ownership through subsidies mainly in the form of interest rates or mortgage quotas to developers and households neglecting other forms of housing provision, for instance social rent.
Pareja Eastaway, Montserrat +1 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source