Results 51 to 60 of about 1,502,099 (298)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The difference that tenure makes [PDF]

, 1991
This paper argues that housing tenures cannot be reduced to either production relations or consumption relations. Instead, they need to be understood as modes of housing distribution, and as having complex and dynamic relations with social classes ...
Andrew Knowles, Bagguley P., Bassett K., Batstone E., Beynon H., Bottomore T., Bradley H., Braverman M., Buck N., Byrne D., Byrne D., Carpenter M., Coates D., Cockbum C., Cooke P., Cousins C., Dahrendorf R., Daunton M. J., de Vroey M., Department of the Environment, Dickens P., Donnison D., Dunleavy P., Ehrenreich B., Forrest R., Forrest R., Gamarnikow E., Goldthorpe J. H., Gordon D. M., Gorz A., Gray F., Hamnett C., Harloe M., Harloe M., Harloe M., Henderson J., Johnson T., Kam V., Kemeny J., Knowles A., Littler C. R., Malpass P., Malpass P., Marshall G., Meegan R., Morris J., Murie A, Murie A., Murie A., Nichols T., Pahl R., Parry N. C. A., Parry N. C. A., Peter Somerville, Pringle R., Rae D. W., Robinson R., Saunders P., Saunders P., Saunders P., Somerville P., Somerville P., Somerville P., Somerville P., Stedman Jones G., Thrift N., Urry J., Willmott P., Wright E. O.   +68 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Resilience in Local Housing Policy? Liberal or Restrictive Policy Stances Among Swedish Municipalities Following the Great Migration in the Summer of 2015

Frontiers in Political Science, 2022
The dramatic event that the great migration in the summer of 2015 entailed changed the migration policies of various countries. Substantial amendments were hastily made in a policy field in which already tense state-local relations struggled to manage ...
Emma Holmqvist, Kristoffer Jutvik, Kristoffer Jutvik, Gustav Lidén   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patterns in Morphological Evolution: Comparing Changes in Six Medieval City-Centres in the Low Countries (1720-2020)

European Journal of Creative Practices in Cities and Landscapes
To the perceptive observer, similarities in the urban structures and architecture of medieval city centres in the Netherlands, Belgium, and a strip of North-Western France will stand out.
Sahar Abdollahi, Martin de Jong, Jurian Edelenbos, Jan Fransen   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Alternatives to social housing: Applicants’ views of various policy options [PDF]

Urbani Izziv, 2015
Privatisation of a large share of the housing stock was characteristic of all central and eastern European countries, which left the majority of these countries with an impoverished social housing sector and therefore little opportunity for housing most ...
Srna Mandič, Maša Filipovič Hrast
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source