Results 61 to 70 of about 1,508,423 (299)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

From Council Housing to Social Housing. The successes and misfortunes of Social Housing policies in Italy

Techne, 2011
The issues dealt with are three: the need for medium – and large – scale territorial planning; the quality of housing; the solutions to guarantee secure flows of financing to launch programmes of public residential housing (ERP).
Ferdinando Terranova
doaj   +1 more source

Neighborhood Unit Concept To Maintain The Quality Of Settlement’s Environment In Perumahan Menara Kudus Area [PDF]

, 2010
The issue of ideal urban housing is frequently discussed in urban housing planning and development. The concept of ideal housing environment desired by urban community is comfortable and safe housing to reside and able to fulfill a well planning standard
Fadjriyah, Ricca, Yuliastuti, Nany
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The difference that tenure makes [PDF]

, 1991
This paper argues that housing tenures cannot be reduced to either production relations or consumption relations. Instead, they need to be understood as modes of housing distribution, and as having complex and dynamic relations with social classes ...
Andrew Knowles, Bagguley P., Bassett K., Batstone E., Beynon H., Bottomore T., Bradley H., Braverman M., Buck N., Byrne D., Byrne D., Carpenter M., Coates D., Cockbum C., Cooke P., Cousins C., Dahrendorf R., Daunton M. J., de Vroey M., Department of the Environment, Dickens P., Donnison D., Dunleavy P., Ehrenreich B., Forrest R., Forrest R., Gamarnikow E., Goldthorpe J. H., Gordon D. M., Gorz A., Gray F., Hamnett C., Harloe M., Harloe M., Harloe M., Henderson J., Johnson T., Kam V., Kemeny J., Knowles A., Littler C. R., Malpass P., Malpass P., Marshall G., Meegan R., Morris J., Murie A, Murie A., Murie A., Nichols T., Pahl R., Parry N. C. A., Parry N. C. A., Peter Somerville, Pringle R., Rae D. W., Robinson R., Saunders P., Saunders P., Saunders P., Somerville P., Somerville P., Somerville P., Somerville P., Stedman Jones G., Thrift N., Urry J., Willmott P., Wright E. O.   +68 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Social Housing and Social Exclusion 2000-2011 [PDF]

By some definitions, social housing, social housing tenants are necessarily socially excluded. In other terms, in 2000, social housing tenants were at greater risk of being socially excluded than owner occupiers and private renters on measures of income,
Rebecca Tunstall
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source