Results 101 to 110 of about 12,306,740 (360)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Learning relationships from theory to design [PDF]

, 1999
This paper attempts to bridge the psychological and anthropological views of situated learning by focusing on the concept of a learning relationship, and by exploiting this concept in our framework for the design of learning technology.
Fowler, C.J.H., Mayes, J.T.
core   +4 more sources

Network centrality, group density, and strength of social identification in college club sport teams

, 2019
Objective: With the underlying rationale that social identification is related to psychological health and well-being, we aimed to understand how social connections and group structure within college club sport teams relate to students’ perceptions of ...
S. Graupensperger, Michael J. Panza, M. B. Evans   +2 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Six month durability of targeted cognitive training supplemented with social cognition exercises in schizophrenia. [PDF]

, 2020
Background:Deficits in cognition, social cognition, and motivation are significant predictors of poor functional outcomes in schizophrenia. Evidence of durable benefit following social cognitive training is limited.
Biagianti, Bruno, Brandrett, Benjamin, Fisher, Melissa, Hooker, Christine I, Howard, Elizabeth, Miley, Kathleen, Nahum, Mor, Ramsay, Ian, Rowlands, Abby, Vinogradov, Sophia, Woolley, Josh   +10 more
core   +1 more source

Identification with social groups is associated with mental health in adolescents: evidence from a Scottish community sample [PDF]

, 2015
The promotion and maintenance of mental health is an increasingly important societal issue. Previous research has shown that identification with social groups is positively associated with adult mental wellbeing, with multiple group identifications being
Baksheev, Bennet, Bennet, Birchwood, Bizumic, Bourdieu, Cano, Cruwys, Cruwys, Doosje, Goldberg, Goldberg, Goldberg, Hardy, Haslam, Haslam, Haslam, Haslam, Haslam, Haslam, Iyer, Jetten, Jones, Kessler, Kessler, Kessler, Levine, Levine, McGorry, Meltzer, Platow, Post, Rosenthal, Sani, Sani, Sani, Sani, Sawyer, Scottish Executive, Scottish Government, Tajfel, Tomasello, Tuomela, Turner, Viner, Wakefield, Wang, Wegge   +47 more
core   +2 more sources

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Bluetooth familiarity: methods of calculation, applications and limitations [PDF]

, 2007
We present an approach for utilising a mobile device’s Bluetooth sensor to automatically identify social interactions and relationships between individuals in the real world.
Byrne, Daragh, Gurrin, Cathal, Jones, Gareth J.F., Lavelle, Barry, Smeaton, Alan F.   +4 more
core  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source