Results 91 to 100 of about 39,434 (269)

Hominin cognitive and behavioural complexity in the Pleistocene: assessment through identity, intentionality and visual display

open access: yes, 2011
The Social Brian Hypothesis predicts the cognitive ability of hominin species by utilising estimated brain and group sizes in relation to an ordinal scale of cognitive complexity expressed as orders of intentionality.
Cole, James Nathan
core  

The influence of fine art photography on the perception of social issues: analysis of works on emigration and identity

open access: yesClío
The study explored the visual impact of Fine Art photography on public perceptions of social issues, focusing on migration and identity. Using an interdisciplinary approach, the research combined visual studies, semiotics, iconography, and social theory.
Anastasiia Terentieva
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Digital selves, digital scholars: Theorising academic identity in online spaces

open access: yes, 2016
As the digital world becomes enmeshed with our physical world, identities become public by default, and this can have disastrous consequences for those whose digital identities are deemed socially unacceptable.
Couros, Alec, Hildebrandt, Katia
core  

"Let Them Speak their Peace": A Retrospective Critical Race Exploration of Adolescent Black Male Social and Schooling Experiences, Identity Development, and Educational/Life Outcomes in Pittsburgh [PDF]

open access: yes, 2013
How adolescent black males make meaning of their social and schooling experiences affects the development of identities that can serve as risk-factors for acedemic engagement, achievement, and life outcome. Although research on racial and ethnic identity
Quigley, Michael
core  

Complexity and identity reconstruction in second language acquisition Complexidade e reconstrução de identidade na aquisição de segunda língua

open access: yesRevista Brasileira de Linguística Aplicada, 2009
The participation of the individual in different discursive practices contributes to the social formation of identity which is not only constituted, but also, fractalized and emerged via discourse.
Liliane Assis Sade
doaj  

Thinking Complexity with Harrison White: Towards Social Emergence via Indexical Language

open access: yesSociologica
Harrison C. White, a founding giant of the relational turn in Sociology, has left us a monumental model of social emergence based on the interplay of three primitives (identity, control, switching) and two principles (self-similarity, dispersion) of ...
Jorge Fontdevila
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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