Results 71 to 80 of about 2,882,964 (323)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

iSchools and Social Identity ??? A Social Network Analysis [PDF]

, 2009
We analyze the publication co-authorship network of an iSchool faculty community using ???Social Identity Theory??? as the theoretical lens. Initially, we discuss the need for a theoretical framework to analyze and interpret social network data. Then, we
Karunakaran, Arvind, Khabsa, Madian, Kim, Hyun-Woo   +2 more
core  

‘It’s like equality now; it’s not as if it’s the old days’: an investigation into gender identity development and football participation of adolescent girls [PDF]

, 2015
This article explores the influence participating in football has on the development of adolescent girls’ gender identity, an area which currently lacks academic attention.
Butler Judith, Butler Judith, Cockburn Claudia, Connell Raewyn W., Cooper Frederick, Corbett Ken, Culp Rocklynn H., Curry Carol, Durkin Kevin, Erikson Erik H., Flick Uwe, Football Association, Hanya Pielichaty, Harris Margaret, Jeanes Ruth, Jeanes Ruth, Messner Michael A., Nash John, Percy Carol, Schmalz Dorothy L., Swain Jon, Thorne Barrie   +21 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Favoritism Toward Foreign and Domestic Brands: A Comparison of Different Theoretical Explanations [PDF]

, 2019
Five theoretical approaches can predict favoritism toward domestic and foreign brands. This article applies a contrastive perspective to examine social identity, personal identity, cultural identity, system justification, and categorical cognition ...
Anastasia Stathopoulou, George Balabanis, Jiayu Qiao, Khan Uzma, Magnusson Peter, Micevski Milena, Muthén Linda K., Samiee Saeed, Shavitt Sharon, Tajfel Henri, Tourangeau Roger, Turner John C., Zhang Yinlong   +12 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

What is Face Anyway?

, 2018
Face-saving is not a unique Chinese cultural phenomenon. The purpose of this article is to discuss what face really is from a cross-cultural perspective.
Song, JiYing
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source