Results 51 to 60 of about 1,499,898 (261)

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Post-traumatic stress symptom trajectories following exposure to population-level trauma: findings from the COVID-19 Healthcare Staff Wellbeing Survey

BJPsych Open
Background The COVID-19 pandemic has been described as a prolonged societal trauma providing new understanding of long-term post-traumatic stress reactions, both generally and in specific at-risk populations.
Kevin F. W. Dyer, Niamh Hurst, Ciaran Shannon, Julie-Ann Jordan   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Improvement in quality of life and loneliness after the community connections program: a community-based pilot intervention in South Australia

BMC Psychology
Background Reducing loneliness and enhancing quality of life (QoL) are key public health priorities. However, limited empirical research examines the impact of community-based interventions on both loneliness and QoL.
Bryony Jardine, Pei Jie Tan, Ashleigh Powell, Diana Eyers-White, Catherine Mackenzie, Ian Goodwin-Smith, Sandra Robinson, Penny Baldock, Mia Zaccardo, Celina Valente, Camilla Trenerry, Svetlana Bogomolova   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dissemination experiences and preferences from HIV service delivery organizations

Implementation Science Communications
Background Better understanding of how deliverers use research and select interventions can further reduce the gap between developing and delivering effective intervention and implementation strategies, especially in the field of HIV.
Maria Pyra, Morgan Purrier, Dennis Li, Kathryn Macapagal, Nanette Benbow   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

International Symposium on “Social Impact and the Social Sciences: Theory and Practice in the Era of Propaganda, Fake News and Media Manipulation”, 5-6 December 2019

Sociologie Românească, 2019
Between 5 and 6 December 2019 the International Symposium “Social impact and the social sciences: Theory and practice in the era of propaganda, fake news and media manipulation” was held at the University of Bucharest.
Ioana Ramia
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source