Results 61 to 70 of about 1,499,898 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Brokering Employment Pathways from Supported Employment Settings to the Mainstream Labour Market

Disabilities
In Australia, many people with a disability work in Supported Employment Settings (previously known as Australian Disability Enterprises or ADEs). SESs are in a unique position to provide training and support to people with a disability as a transition ...
Perri Campbell, Andrew Joyce, Erin Wilson, Robyn Eversole, Jenny Crosbie   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Role of Muslim Religious Code of Conduct (Islamic Law or Shariah) in Child Protection Within Muslim Migrant Communities in Australia

Religions
This paper investigates and examines the role of the Muslim religious code of conduct known as Sharia or Islamic law in relation to the protection of children, in particular child neglect, within Australian Muslim communities. Australia has a secular and
Hossein Esmaeili, Nada Ibrahim
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Role of Shared Resilience in Building Employment Pathways with People with a Disability

Disabilities
For workers living with a disability, pathways to sustainable employment in the open labour market are inhibited by barriers operating at different structural and societal levels.
Perri Campbell, Erin Wilson, Luke John Howie, Andrew Joyce, Jenny Crosbie, Robyn Eversole   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Partially divided caging reduces overall aggression and anxiety which may indicate improved welfare in group housed male C57BL/6J mice

BMC Veterinary Research
Deciding which environmental enrichment is used in mouse caging is often subjective, with cost frequently prevailing over welfare benefits, including aggression and anxiety.
Bret R. Tallent, L. Matthew Law, Jonathan Lifshitz   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Strengths, Gaps, and Challenges in the Decision-Making Processes in the Design of the National Disability Insurance Scheme, Australia

Administrative Sciences
This study examines the decision-making processes that were used in the development of the National Disability Insurance Scheme (NDIS). It draws on research that highlights that decision-making can be improved if organisations follow specific decision ...
Andrew Joyce, Gemma Carey, Fiona Buick
doaj   +1 more source