Results 231 to 240 of about 1,025,463 (296)

The Protective Role of Social Inclusion: Loneliness as a Mediator Between Excessive Internet Use and Depressive Symptoms in Adolescents. [PDF]

Psychol Res Behav Manag
Zhou J, Zhu N, Suwada K, Toikko T.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Boosting scientific community values: The impact of social inclusion interventions on biomedical instructors. [PDF]

J Clin Transl Sci
Hernandez PR, Du W, Aldana CC, Broderick NA, Handelsman J, Lee H, Luo L, Maldonado N, Miller HA, Miller S, Patterson M, Pedersen R, Sandoval P, Vong J, Estrada M.   +14 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Social inclusion for individuals with developmental disabilities in the Middle East. [PDF]

Int J Dev Disabil
Gaad E, Alborno N.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Leaving Care in the Nordic Countries – Young People’s Experiences During Transitions to Adulthood

Nordisk Välfärdsforskning
Anne-Kirstine Mølholt, Stian H. Thoresen, Zulmir Bečević   +2 more
doaj   +1 more source

Barriers and facilitators to social inclusion among people with severe mental illness: A qualitative study. [PDF]

PLOS Ment Health
Eager S, Lloyd-Evans B, Bousfield J, C J, Downey M, Harrison I, Killaspy H, Mezey G.   +7 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The promotion of social sustainability by micro-level social inclusion in a multicultural context: literature review and interview evidence. [PDF]

Front Sociol
Fan Q.
europepmc   +1 more source