Results 101 to 110 of about 2,252,232 (307)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Social indicators and the study of inequality - commentary [PDF]

Economic indicators ; Public policy ; Income distribution ; New York (N.Y.)
Howard Chernick
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Regional Growth Convergence in Colombia Using Social Indicators [PDF]

This paper investigates convergence in social indicators among Colombian departments from 1973 to 2005. We use census data and apply both the regression approach and the distributional approach (univariate and bivariate kernel density estimators).
Adriana Cardozo, Boris Branisa
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Public policy and the social determinants of health: the challenge of the production and use of scientific evidence

Cadernos de Saúde Pública
This article serves as an introduction to the others published in this thematic issue of the Cadernos de Saúde Pública. The author makes a brief historical review of the concepts, approaches and methodologies used to study the relationships between ...
Alberto Pellegrini Filho
doaj  

EVALUATION OF A CONCEPTUAL QUALITY OF LIFE MODEL BUILT FROM DATA

Acta Colombiana de Psicología
Quality of Life (QL) is a concept used by different disciplines. However, there is a variety of definitions of QL, which might lead to theoretical and applied problems.
Natalia Cancino, Catalina González, Ismael Gallardo, Claudia Estrada   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Incorporating social indicators for an equitable carbon budget allocation among different geographical regions

Environmental Research Communications
As the global temperature continues to rise each year, limiting global warming to 1.5 °C is increasingly becoming a challenge due to the shrinking size of the remaining carbon budget.
Syeda Tasnia Hasan, Michael O Wood, Horatiu A Rus, Simron Jit Singh, Tingting Wu   +4 more
doaj   +1 more source

The Impact of Social Capital on Crime: Evidence from the Netherlands [PDF]

This paper investigates the relation between social capital and crime. The analysis contributes to explaining why crime is so heterogeneous across space.
Akçomak, I. Semih, ter Weel, Bas
core