Results 101 to 110 of about 2,350,942 (296)

Innovations sociales, innovations économiques

Calenda, 2013
Le colloque investira le champ d’interrogations autour de l’innovation et de sa dualité, à la fois au cœur de la recherche de compétitivité économique (avec ses implications sociales d’investissement dans le capital humain et de maîtrise de la cohésion sociale) et en même temps au cœur des nouvelles aspirations sociales (nouvelles formes de solidarité ...
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Learning from volcanic eruptions: Co-production of knowledge at Merapi and Kelud, Indonesia

Jàmbá
The increasing frequency and intensity of volcanic disasters present major challenges for rural communities, particularly in terms of recovery and the restoration of environmental conditions post-crisis.
Nuzul Solekhah, Fatwa N. Hakim, Eko Wahyono, Reza A. Prayoga, Siti Fatimah, Lis Purbandini, Djoko P. Wibowo, Rachmini Saparita, Febby Febriyandi YS, Muhammad Alie Humaedi   +9 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Character and Impact of Social Innovation in Higher Education. [PDF]

, 2012
This article offers a strategic multi-layered model for assessing the character and impact of social innovation in higher education connecting social and economic benefit.
Elliott, Geoffrey
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Innovation and Social Capital in the Small-Medium Enterprises: a case of bamboo handicraft in Indonesia [PDF]

This paper aims to seek what type of innovation and to estimate the impact of social capital on the innovation in the small-medium enterprises (SMEs) in Indonesia.
Brata, Aloysius Gunadi
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Innovation: A Guide to the Literature [PDF]

Innovation is not a new phenomenon. Arguably, it is as old as mankind itself. However, in spite of its obvious importance, innovation has not always got the scholarly attention it deserves. This is now rapidly changing, however.
Jan Fagerberg
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source