Results 91 to 100 of about 326,825 (263)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Non-Invasive Techniques for Monitoring Cultural Heritage: Change Detection in Dense Point Clouds at the San Pietro Barisano Bell Tower in Matera, Italy

Heritage
This study examines change detection techniques in dense point clouds for the purpose of cultural heritage preservation, with a particular focus on the San Pietro Barisano Bell Tower in Matera, Italy.
Carmen Fattore, Sara Porcari, Arcangelo Priore, Vito Domenico Porcari   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impact of genetically modified Brinjal (Bt brinjal) on farmers’ income and production in Pabna District, Bangladesh

GM Crops & Food
Approval of Bt brinjal cultivation represents a crucial step forward for Bangladesh in agricultural biotechnology. However, the scalability of Bt brinjal adoption faces barriers, mainly due to resistance from traditional farmers, the limited evidence ...
Md Amzad Hossain, Kazi Khalid Hossain, Niraj Prakash Joshi   +2 more
doaj   +1 more source

Supporting the creation and installation of regional social innovations with knowledge engineering system

Marketing i Menedžment Innovacij, 2017
The aim of the article. The aim of the article is identification of essence and features of application of social innovation in the current economic conditions of the Republic of Hungary.
G. Kocziszky, M. Veresné Somosi
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Learning from volcanic eruptions: Co-production of knowledge at Merapi and Kelud, Indonesia

Jàmbá
The increasing frequency and intensity of volcanic disasters present major challenges for rural communities, particularly in terms of recovery and the restoration of environmental conditions post-crisis.
Nuzul Solekhah, Fatwa N. Hakim, Eko Wahyono, Reza A. Prayoga, Siti Fatimah, Lis Purbandini, Djoko P. Wibowo, Rachmini Saparita, Febby Febriyandi YS, Muhammad Alie Humaedi   +9 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Influence of health food literacy on willingness to pay for healthier foods: focus on food insecurity

International Journal for Equity in Health
Background The repercussions of food insecurity are widely recognized to negatively impact overall health and are influenced by a complex interplay of physiological, psychological, social, and environmental factors.
Su-Jung Nam, Jaehye Suk
doaj   +1 more source

The Diffusion of Innovations in Social Networks [PDF]

, 2005
AbstractThis chapter examines the effects of network topology on the diffusion of behaviors. A key empirical question is, what is the expected length of time for a network to “switch over” from the old behavior to the new? It uncovers conditions on network topology the decision process that, surprisingly, bound the expected waiting time for diffusion ...
openaire   +3 more sources